Prescribers must screen for contraindications including current or past seizure disorders, eating disorders (anorexia nervosa or bulimia nervosa), abrupt withdrawal from alcohol or sedatives, severe hepatic impairment, and use of other medications that lower seizure threshold
In particular, while several studies suggest that -3 PUFA consumption has protective effects on the development of autoimmune thyroiditis [122], others demonstrate that exposure to pollutants (especially heavy metals) that contaminate fish is associated with an increased risk of autoimmunity and thyroid dysfunction [121,124,125,126]
Fibroblast Kinetics: The acceleration of fibroblast migration and proliferation in tendon and ligament tissue models
doi:10.1210/endo.139.7.6092 41
For best results on hyperpigmentation, it should be combined with good skincare (brightening creams, exfoliants, sun protection) and possibly other dermatologic treatments, depending on the severity of the issue