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Characteristics of included studies Among the included trials, 119 (45.4%) were randomized controlled trials (RCTs) and the majority (80.5%) focused on adult populations

doi: 10.1111/and.2018.50.issue-8 4 WalczakJedrzejowskaRWolskiJKSlowikowskaHilczerJ

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doi: 10.1186/s40478-020-01031-3 148 SchillingSChausseBDikmenHOAlmouhannaFHollnagelJOLewenAet al

AGE-RELATED CHANGES IN GROWTH HORMONE SECRETION The trophic hormones that rise at puberty, including sex steroids and GH, have dramatic effects on body composition and strength