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In the context, Figure 2 shows that GLP-1RA-driven microbiota changes coordinate SCFA and bile acid signaling, promoting WAT beiging and gut-brain axis-mediated energy balance

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A blinded extension among participants with baseline BMI 35 reached mean weight loss of 30.3% at 104 weeks

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Multiple studies demonstrate that when people stop using these medications, they regain most of the weight lost within a few months unless they have made diet and lifestyle changes