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Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor via direct and indirect mechanisms

Furthermore, treatment with the zinc ionophore zinc pyrithione (ZnPTO, a membrane-permeable compound containing a zinc atom 51 ) without high glucose was sufficient to induce -cell identity loss, manifested as a reduction in cells and an increase in cells and bi-hormonal INS + GCG + cells in human primary islets (Supplementary information, Fig

Absence of expected improvement by mid-protocol (4-6 weeks) warrants reassessment

J.BallL.OxboroughK.KarpinskiS.MullineauxP

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