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In available research it's been generally well-tolerated, but human data is limited and it's not FDA-approved which is why supervision and medical-grade sourcing matter

doi: 10.2337/diabetes.52.1.124 20 CouvineauALaburtheM

This decrease in caloric consumption, combined with potential gastrointestinal side effects such as nausea, vomiting, and diarrhoea, may increase the risk of micronutrient deficiencies in certain individuals

Managing heart rate increases on retatrutide The clinical trial data suggest several evidence-based approaches to managing retatrutide heart rate effects