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Originally developed from the peptide Melanotan II, PT-141 was refined to specifically target sexual function without the unwanted side effects

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Prunes or prune juice provide both fiber and sorbitol, which has a mild laxative effect

However, caution should be taken when interpreting these results due to short follow-up periods (i.e., 1.11.4 years [18,19,20]), the possibility of confounding bias caused by the inclusion of advanced T2D cases (i.e., requiring intensive insulin therapy [18]), uncertain liver effects (e.g., incident NAFLD) of active comparators (i.e., DPP4is [19, 20] and insulin [18]), lack of dose-response analysis, and limited generalizability to other ethnic populations