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The specific metabolic benefit appears to result from gut bacteria modifications, increased Bifidobacterium and decreased Firmicutes species

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However, because this excretion accounts for less than 1% of total acylcarnitine elimination in urine [43], it is unlikely that excretion of VPA alone is sufficient to produce carnitine deficiency in well nourished patients [44]

S d,d is the stoichiometry matrix for the dynamic module variables and dynamic module reactions, S s,d is for the static module variables and dynamic module reactions, and S s,s is for the static module variables and static module reactions