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Precision-medicine frameworks now aim to classify PD patients into microbiome-immune subtypes, allowing for specific combination therapies, such as pairing SCFA-restoring strategies with T-cell modulation in Th17-dominant endotypes or combining barrier-repair interventions with microglial inhibitors in patients with strong peripheral-to-central inflammatory coupling

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FBS, fasting blood sugar

The amount of SC removed depends on factors including anatomical site, pH and transepidermal water loss [278]

Millimolar concentrations of tBOOH induce changes in RBC deformability 16,17 , and our study adds to these observations by exploring the timeline of damage while RBC also experience shear stress