The runners high phenomenon describes an acute, noticeable elevation in mood after a bout of physical exertiondue to, researchers have found, immediate changes in dopamine. Exercising hits two birds with the same stone: It provides long-term quality of life insurance, while also accelerating your weight loss on GLP-1s
In diabetes and obesity, growth factor-associated signaling in the brain deteriorates and energy use in the cerebral cortex decreases simultaneously with pro-inflammatory changes, while GLP-1RAs improve neuronal growth and repair, reduce inflammation and apoptosis, as well as oxidative stress [31]
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
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For example, Dominos share prices have fallen following the recent announcements around GLP-1RAs (although they have since partially recovered)