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cerevisiae , Sic1, and its kinase-inhibitor domain, and showed that the isolated Sic1 KID populates collapsed states of different compactness, including a metastable, highly compact species ( 2.13.3 Native mass spectrometry (nMS) Native mass spectrometry (nMS, which is a form of electrospray ionization mass spectrometry (ESI-MS)), being a relatively recent addition to the analytical toolbox of mass spectrometry, can be used to measure the size, stoichiometry, and interactions of macromolecules (such as proteins) in their native, folded state, thereby directly exploring the different conformational components in terms of geometry and structural compactness (Konijnenberg et al., 2015

How big that shift is, and whether it shows up reliably, leans heavily on the cell source and how many times the cells have been passed

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