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Endpoints and Assessments The primary study objective was to confirm bioequivalence of the two oral formulations of semaglutide (2G vs 1G) administered once daily at three dose levels at SS in healthy participants, namely 2G oral semaglutide 1.5 mg versus 1G oral semaglutide 3 mg, 2G oral semaglutide 4 mg versus 1G oral semaglutide 7 mg, and 2G oral semaglutide 9 mg versus 1G oral semaglutide 14 mg

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Furthermore, proBDNF could serve as a reservoir for the mature molecule, and an increase in proBDNF suggests a larger BDNF deposit that is likely associated with greater genetic transcription (e.g., epigenetic regulation)

In 39 patients (19 in the loading dose group and 20 in the no loading dose group), MMSE scores were similar at baseline (27 vs