Ritter W, Paavilainen P, Lavikainen J, Reinikainen K, Alho K, Sams M et al (1992)
PLoS ONE 9 , e100778 (2014)
This timing leverages physiologic factors including reduced somatostatin inhibition during sleep, increased GHRH receptor sensitivity during evening hours, and optimal metabolic conditions supporting growth hormone synthesis and secretion, while morning or midday administration stimulates smaller daytime pulses with less consistent metabolic benefits
Plan the dose to fall shortly before a meal, matching how the trials timed exposure to dietary antigens
Citicoline for acute ischemic atroke: a systematic review and formal meta-analysis of randomized, double-blind, and placebo-controlled trials