Mol Cell Proteomics (2019) 18(3):50419
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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)
Hence, direct IR-related adverse side effects may develop as a result of increased oxidative stress, and ROS-related diseases may also develop
This led to the development of exenatide and subsequent GLP-1 receptor agonists, which are now widely used to treat type 2 diabetes by enhancing insulin secretion, slowing gastric emptying, and reducing appetite