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Another study in the Journal of the American Medical Association notes that among those with diabetic nephropathy (loss of kidney function due to diabetes), combining vitamin B6 (25 mg) and folic acid (2.5 mg) (B-complex vitamin) with 1,000 mcg of oral B12 per day for six years increases the risk of cardiovascular events, including heart attack and stroke

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Known copper allergies also contraindicate use

This could be due to a variety of reasons such as genetic factors, underlying health conditions like pernicious anaemia, or gastrointestinal surgery

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