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Clathrin-mediated endocytosis (CME) usually requires arrestin to act as a scaffolding protein to link the receptor to the 2-adaptin subunit of adapter protein 2 (AP2), which then targets the receptor to clathrin-coated pits ( via clathrin-coated pits is an arrestin-independent process for GLP-1R (Syme et al., 2006

Edsall G, Gaines S, Landy M, Tigertt WD, Sprinz H, Trapani R-J, Mandel AD, Benenson AS (1960) Studies on infection and immunity in experimental typhoid fever: I

However, in older adults with obesity refractory to lifestyle strategies, pharmacotherapy, using anti-obesity medicines (AOMs), can be a useful adjunct

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