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Notably, iron overload can cause inequalities in the proportion of CD4+ and CD8+ T cells, a rise of ROS levels in T cells, and DNA damage (91)

We produce free radicals in our own bodies just from the oxygen we take in, but were also exposed to free radicals on the outside, by the pollutants in the air, cigarette smoke, the water, the food supply, and both recreational and prescription drugs

ACSL4 is highly expressed in OA synovial tissue, while the key antioxidant enzyme GPX4 expression is significantly reduced

[PubMed] [Google Scholar] 65.Gerl A., Schierl R

An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences