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Research shows that some people taking a PPI may benefit from magnesium supplementation if a deficiency is present, as confirmed by [a] physician. Meacham also emphasizes the importance of anyone with a known medical condition consulting their doctor before taking a dietary supplement

Treatment with dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase, increases pyruvate dehydrogenase activity and systolic blood pressure in 34 weeks old SHR and WKY rats 55

Li Z, Wang W, Xin X, Song X, Zhang D