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Phosphorylation sites have been reported on CSE, which modulates its activity

Stopping diabetes or obesity medication without medical guidance can lead to deterioration in metabolic control and increased cardiovascular risk

Can tirzepatide help with stronger appetite control

Spiering BA et al

So it was very important for our chain of thought and decision early on that we actually knew that GLP-1 had these separate effects and that they could work in the brain and have a separate effect on well-known pathways in the brain