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Glucosamine is not recommended during pregnancy or breastfeeding due to insufficient safety data, is not advised for those under 18 years of age, and should be used with caution in people with asthma as exacerbations have been reported

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Common patch ingredients (berberine, green tea extract, cinnamon) have modest metabolic evidence when taken orally at high doses, but zero published pharmacokinetic data shows they absorb through the skin from an adhesive patch at therapeutic levels