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Antioxidant Interventions in Hashimoto's: The Clinical Evidence While direct human clinical trials of oral glutathione supplementation specifically for Hashimoto's thyroiditis are still limited, the evidence from related antioxidant interventions is highly instructive: A comprehensive systematic review and meta-analysis published in Thyroid (2024) - conducted by researchers at the University of Bern, Switzerland - analyzed 35 randomized controlled trials (RCTs) involving 2,358+ participants with Hashimoto's thyroiditis

Most published evidence sits in in-vitro studies, animal models, and small cosmetic-research panels

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However, high doses ( 0.5 mg/kg/d) may activate the SREBP-1c pathway, increase liver fat synthesis, and lead to hypertriglyceridemia and fatty liver

This selectivity ensures it triggers an immediate GH release without significantly affecting other hormones like cortisol or prolactin