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Synaptic and extrasynaptic NMDAR activation exert opposing neural protective and neurotoxic effects, respectively, and these processes involve a variety of corresponding neuroprotective and apoptotic pathways ( Metabotropic Glutamate Receptors Glutamate can also activate a type of G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs)

From a therapeutic standpoint, pharmacological inhibition of SLFN4 either through small molecules like sildenafil or genetic approaches has demonstrated efficacy in preclinical models

Traditional GH Therapy Traditional GH therapy uses synthetic hormone injections

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