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In the foundational 2017 Cell study, naturally aged mice and chemotherapy-treated mice received FOXO4-DRI at 5 mg/kg by intraperitoneal (IP) injection , given on an intermittent schedule (about three times per week) across several weeks

Compared with the peptide-free apo and intermediate state structures, compound 2 rendered the TM bundle and the ECD of GLP-1R undergo extensive conformational transitions (Supplementary Figs

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