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H 2 S production, measured using the 7-AzMC fluorogenic probe as previously described (Figures 2E, D YRK1A expression in HepG2 cells induced a significant increase in H 2 S production without affecting cell proliferation and/or viability (Supplementary Figure 1C), whereas two mutant forms of DYRK1A (p.S324R and p.S311F) that had lost their kinase activity ( 2 S production (Figure 2E)

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Obesity is closely associated with an increased risk of multiple cancers, and NNMT overexpression acts as a key mediator linking obesity and cancer: in the obese state, elevated NNMT activity leads to metabolic disorders and promotes cancer cell proliferation.By inhibiting NNMT activity, 5-amino-1mq liquid regulates systemic metabolism, reduces fat accumulation, and suppresses the occurrence and progression of obesityrelated cancers, providing a novel strategy for the prevention and treatment of such cancers

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