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In 1931, during the Great Depression, Texas and other states created a movement that sought to "reform the administrative machinery, and to reduce the high cost of state government." [4] The Texas Legislature enrolled Griffenhagen and Associates, "specialists in public administration and finance who had worked on similar projects throughout the United States and Canada, to make a survey and act as consultants." [4] The firm concluded that Texas' exceptional geographic size caused the Rangers and the License and Weight Division to struggle in providing adequate enforcement across the entire state
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TIMP-1 showed inconsistent regulation between different biological compartments in women with endometriosis, with reported decreases in blood and ovarian tissue and an increase in peritoneal fluid across well-powered cohorts [22, 81]
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The exceptional in vitro potency is attributed to its mechanism of acting as an allosteric potentiator of HGF binding to c-Met (amplifying an endogenous signal), which produces non-linear dose-response curves
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