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Many inhibitors also have off-target effects, which become more pronounced at high concentrations

24 For further information on the decision to fund these medicines, see: People at high risk of cardiovascular and renal complications will benefit Several large randomised controlled trials (RCTs) have shown that treatment with a SGLT-2 inhibitor or GLP-1 receptor agonist provides significant cardiovascular benefit to people with type 2 diabetes

These medications slow gastric emptying, which helps regulate digestion and fosters a healthier gut environment

The system accounts for real-life variability

Patients with complex medical histories, psychiatric conditions, sleep disorders, cardiovascular concerns, autoimmune conditions, pregnancy considerations, or multiple medications should be especially cautious