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The only double-blind non-randomized clinical trial conducted in the 1980s was the subject of a Cochrane Systematic Review, which found inconsistent results regarding its benefits for children and no evidence of effectiveness in adults

[64] Consequently, considering the potential biphasic effects of GABA on growth hormone production, as well as other safety concerns, its usage is not recommended during pregnancy and lactation

The table below summarizes markers and their clinical relevance

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