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The recent US approval of semaglutide for fibrotic metabolic dysfunction-associated steatohepatitis is likely to add relatively few newly eligible patients because most already qualify for treatment through existing indications for obesity or high-risk type 2 diabetes, a population-based analysis found

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The proportion of patients achieving HbA1c of less than 7 % without severe or confirmed episodes of hypoglycaemia and without weight gain was significantly higher with semaglutide at doses of 0.5 mg and 1 mg (up to 66 % and 74 %, respectively) versus patients treated with sitagliptin (27 %), exenatide ER (29 %), insulin glargine (16%), dulaglutide 0.75 mg (44 %) and dulaglutide 1.5 mg (58 %)

Sarkaya E, Doan S