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To measure neurite growth, 45,000 cells per well were plated to ensure outgrowth at sufficiently low density to allow quantification

This step only needs to be done once per vial

These viral mimetic NPs do not have immunogenicity and could efficiently deliver genetic material to the brain by exploiting natural cellular uptake processes

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JFE, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB

Analyzing four studies from the meta-analysis that evaluated remission, the remission rates were maintained at 66.2% at 3 months, 46.3% at 1 year, and 42.1% at 2 years [474,475]