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Hypoglycaemia risk is generally low with GLP-1 agonists alone but may be elevated when combined with insulin or sulfonylureas, particularly in patients with poor nutritional status or irregular eating patterns

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2 CKD confirmatory secondary endpoints Significant 18% RRR of MACE with Ozempic 2 For adults with T2D and CKD, for a confirmatory secondary endpoint: Time to first occurrence of MACE (CV death, nonfatal MI, or nonfatal stroke) vs placebo when both were added to standard of care 1,2 Time to first MACE 1-3,w-z 1-3,w-z w Cumulative incidence estimates are based on time from randomization to first EAC-confirmed MACE with non-CV death modelled as a competing risk using the Aalen-Johnson estimator

Drug Delivery and Translational Research