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doi: 10.3389/fimmu.2025.1730346 Received 22 October 2025 Revised 14 November 2025 Accepted 17 November 2025 Published 08 December 2025 Volume 16 - 2025 Edited by Moanaro Biswas, Indiana University, United States Reviewed by Narendra Chirmule, Indian Institute of Technology Bombay, India Andrea Di Ianni, Merck, Germany Updates Copyright 2025 Mattei, Roberts, Lelias, Miah, Howard, Weaver, Verthelyi, Pang, Edwards and De Groot