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Additional increases to 70 mg/day were made as tolerated and clinically indicated

As previously mentioned, researchers have suggested that MMPs play a vital role in the pathogenesis of endometriosis as these proteolytic enzymes are increased during extracellular matrix (ECM) remodeling of the endometrium [105]

Adverse health effects have been observed at both extremes of intake, with a narrow optimum range

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The supernatant was added to beads (equilibrated with 200 mM NaCl, 50 mM TrisHCl, pH 7.5, 10% glycerol, 5 mM choline chloride, 0.05% LMNG) in a 10-ml gravity column at 4C and sequentially washed with 2 1 ml of buffer containing 0.01% LMNG