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Similarly, DSePA, another interesting organoselenium compound, has shown potent efficacy as a lung-specific radiomitigator through inducing the expressions rather than mimicking the activities of seleno-GPxs, thus warranting future clinical studies [61, 62]

Ann Oncol 18:14571466 Darcy MS (2019) Cell death: a review of the major forms of apoptosis, necrosis and autophagy

Similar to albumin, AAT can function as an indirect free radical scavenger by interacting with neutrophil alpha defensins, 159-161 free fatty acids, 162 and free heme

Lack of dosing safety studies: Even small differences in dose may lead to drastically different outcomes due to its extreme potency