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Because GPCI adjusts each component separately by locality, a practice in Manhattan will receive a different payment than one in rural Arkansas for the same code

This has led some researchers to target 9mg rather than 12mg as their maintenance dose, especially given that the difference (2.3 percentage points) may not justify the additional side effect burden for all individuals

This is an area of early research interest in longevity science, as maintaining genomic integrity may support overall cellular health and healthy aging pathways

Hooshmand B et al., Neurology 2010 B12 status and brain volume in elderly

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