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Diarrhea occurs in approximately 30% of patients taking semaglutide 2.4 mg (Wegovy) and 19-23% of patients taking tirzepatide (Zepbound) according to FDA prescribing information

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Interaction with GLP-1 receptor-expressing neurons here produces further activation of important brain nuclei, including the paraventricular and the arcuate nucleus, the nucleus of the solitary tract and the nucleus ambiguous, the bed nucleus of stria terminalis, the central nucleus of the amygdala and the parabrachial nucleus [10]

The amount of physical activity your healthcare provider recommends may vary depending on your individual circumstances