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The effect of a high-fat diet on -cells is an inhibition of the increased cytosolic pH that is necessary to trigger Smad5 interaction with V-ATPase and the subsequent acidification of insulin secretory vesicles

doi: 10.1016/S0021-9258(18)99181-7 148 PetersonCTRodionovDAOstermanALPetersonSN

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Activation of jr PPO1-wt was tested using different molarities of salts (NaCl, KCl, MgCl 2 and CaCl 2 ), all of which resulted in active enzyme with the divalent ions (Mg 2+ and Ca 2+ ) requiring lower molarities than the monovalent ions (Na + and K + ) (Fig