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Major clinical programs did not identify depression as a frequent drug-related event in primary safety tables

3i,j), as was the effect of acyl-GIP on glucose tolerance (Fig

Disruption of the signals constituting this axis is thought to be a common pathophysiological pathway that leads not only to unwanted weight gain and the development of obesity, but is now also recognized to be a key mediator in the development of metabolic disorders such as dyslipidemia, prediabetes, and type 2 diabetes

As weight loss drugs, semaglutide was approved as Wegovy in 2021 and tirzepatide was approved as Zepbound in 2023

doi:10.3390/ijms22041967