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Mitochondrial translocation of P66Shc aggravates cisplatin-induced AKI by promoting ferroptosis

7, 13084 doi: 10.1038/ncomms13084 (2016)

In a recent double-blind, randomized, placebo-controlled trial in women with abnormal mammograms, two-to-eight week consumption of about 250 mg/day of broccoli seed extract (~220 mg of glucoraphanin/day) before surgery failed to affect the expression of markers of proliferation and gene expression, including ki-67, p21, HDACs, and acetylated histones, in breast tissues collected after surgery (62)

For instance, adverse events reported after intravenous glutathione included nausea, vomiting, chills, low blood pressure, breathing difficulty, possible bloodstream infection