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Low-dose lithium , promoted for brain aging after a 2025 Harvard study showed brain lithium is depleted early in Alzheimers and that lithium orotate reversed pathology in mice, has only mixed human trial evidence and works by dampening neuronal firing, so I do not recommend it for a healthy brain

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Importantly, a series of standardized toxicological assessments confirmed the safety of UA, showing favorable profiles in both human and animal models, with minimal side effects (7, 9)

Furthermore, there was a significant 8-fold increase in the growth of BCG inside granulomas from T2DM subjects compared to the healthy subjects ( Figure 2B )