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In a 2025 report on the lidERA breast cancer trial, giredestrant reduced any recurrence by 30% and distant or metastatic recurrence by 31% versus tamoxifen or an aromatase inhibitor, with 92.4% recurrence-free survival at three years compared with 89.6% for standard hormonal therapy, according to Breastcancer.org's report on the lidERA trial

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