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doi: 10.3390/plants9020196 6 DengY.YangP.ZhangQ.WuQ.FengL.ShiW.et al
3 To prevent excessive oxidative stress and maintain favorable redox homeostasis, tumor cells have evolved a complex antioxidant defense system that strategically adjusts multiple antioxidant enzymes such as catalase, glutathione reductase, and antioxidant molecules
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The latest research has found that dihydroorotate dehydrogenase (DHODH) in mitochondria can regulate ferroptosis through a GSH-independent pathway, which provides a new idea for precise targeted regulation of ferroptosis (38)
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