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Under acidic conditions, it not only sustains ROS generation but also allows controlled release of antibiotics ( Similarly leveraging acidic conditions for antibacterial activity, Na 2 S 2 O 8 @ZIF-67/GOx(composed of sodium persulfate, Na 2 S 2 O 8

Reconstitution & Handling Guidelines Because of the highly concentrated peptide mass (80mg) and the inclusion of the copper ion complex, reconstitution must be handled methodically to avoid shearing the peptide bonds: Recommended Solvent: Bacteriostatic Reconstitution Solution (0.9% Benzyl Alcohol)

ROS and necroptosis (type III programmed cell death) ROS are also able to induce necrosis, which was originally considered an unregulated form of cell death but is now recognized as type III programmed cell death (necroptosis) 121,122

121 SripetchwandeeJ.SanitJ.ChattipakornN.ChattipakornS

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