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Although PTX exerts significant cytotoxic effects in the treatment of advanced GC, a considerable proportion of patients develop acquired resistance to PTX during administration, ultimately leading to treatment failure 46,47

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In Phase 2 and early Phase 3 trials, the most common side effects were gastrointestinal, including nausea, diarrhea, vomiting, and constipation, which were generally mild-to-moderate and dose-dependent

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