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Polyethylenimine (PEI) NPs delivering GLP-1 genes have improved -cell function and endogenous insulin secretion, and combined nanoparticle systems delivering insulin and GLP-1 agonist genes exhibited synergistic improvements in glycaemic control [219, 220]

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Titration schedules in phase 3 trials of long acting insulin analogues incorporated individualization to allow the clinician to increase the dose to achieve optimal benefit without causing hypoglycaemia ( The oral obesity medications The oral GLP-1 based agents approved for obesity treatment deliver substantial weight loss

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As a result, the individual will gain weight if they return to their regular eating habits