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Arch Pharmacol

The announcement also has the potential to encourage more people into the direct-to-consumer path to accessing expensive drugs, said Benedic Ippolito, an economist at the conservative American Enterprise Institute

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However, concerns about the possible deleterious consequences of such a dosage regimen still remain given that plasma concentrations of trimethylamine-N-oxide were continually rising and approximately doubled in a two-week period

These effects create synergistic benefits that exceed what would be expected from simple addition of single-pathway therapies