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Creatinine was measured by spectrophotometry using the Selectra JR Clinical Chemistry Analyser (Vital Scientific, France)

An HR of 0.79 in favour of orally administered semaglutide compared with placebo was observed, but this 21% reduction in MACE did not reach statistical significance ( p = 0.17 for superiority)

explicitly documented the absence of ACTH and cortisol stimulation at effective ipamorelin doses as a distinguishing feature relative to GHRP-2 and GHRP-6