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The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione

We propose that this class of inhibitors trap the NADP + -TGR(H) species, preventing NADP + release

doi: 10.1038/nrgastro.2015.34 [DOI] [PubMed] [Google Scholar] 4

9 Complete medical histories (inclusive of past and present clinical illnesses, past hospitalizations and surgeries, travel history, family history, medication history, allergies to medications or foods, and immunization status) in conjunction with a thorough physical examination can offer clues to other possible causes of hepatic insult

Although archaea are not classical pathogens, disruption of archaeal populations have been associated with this interspecies network, contributing to metabolic imbalance 46