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Drug administration methods significantly influence therapeutic efficacy, since different delivery systems affect drug absorption, distribution, and metabolism, thereby exerting distinct impacts on energy metabolism, organ function, and behavioral performance
However, participants were from a range of countries representative of those included in the main phase, and comparison of baseline characteristics among the ExAS and FAS indicated that the extension sample was representative
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Policymakers and clinicians should prioritise SGLT2Is for patients with HFpEF, especially those with comorbid diabetes or CKD, to optimise outcomes and resource allocation
