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These include promoting the formation of new blood vessels, supporting collagen production, regulating inflammatory responses, and helping repair damaged tissues

On one hand, IBD can lead to dysregulation of adipokines, shifting the balance towards a pro-inflammatory state, on the other hand obesity and higher BMI are associated with higher risk of developing IBD and worse clinical outcomes, particularly for UC

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While studies have shown that VSMCs express the VLDL receptor and various scavenger receptors, (145,147,148) data showing that these cells robustly load with CE, (147) similar to macrophages via these mechanisms is lacking