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In this study, chronic DEX administration was associated with weight loss, decreased food intake, locomotor retardation, cognitive deficits, anxiety, and behavioural despair, and a number of these symptoms and signs are necessary for the diagnosis of depression in humans

decreased by 4.6 23.9 mg/dL, p = 0.018)

This was consistent with previous studies showing that the liver content of GSH was exhausted after APAP treatment [19-21]

Vitamin C has the unique ability to donate an electron to the spent Glutathione, "wringing it out" and returning it to its active, reduced state

however, some clinical studies have reported reduced weight gain or weight loss following acute use of SERT in persons with depression[67]