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"As a primary care doctor, I encourage patients to think about contraception before starting tirzepatide, especially if pregnancy prevention is important to them, says Daniel McGee, D.O., a board-certified family medicine physician, With some advance planning and, in some cases, temporary use of a backup contraceptive method, most people can safely pursue both goals

For example, the PPAR-LC3 interaction facilitates autophagic degradation of PD-L1 in lysosomes, thereby attenuating immune evasion in NSCLC (139)